2. Vikings CBs vs. Brandon Aiyuk
49ers wide receiver Brandon Aiyuk has shown to be the preferred target of San Francisco quarterback Brock Purdy on offense this season, outside of running back Christian McCaffrey, and with fellow receiver Deebo Samuel out this week, a bigger spotlight will be on Aiyuk.
It's hard to tell who is really the No. 1 cornerback in Minnesota this year, but whoever is tasked with covering Aiyuk on any given play this week, it's key that they find a way to slow him down.
If the Vikings can take away such a big piece of the 49ers' offense, Minnesota will give themself a better shot at winning.
The Vikings' pass defense has shown improvement this season under new defensive coordinator Brian Flores, so it will be a big task to see how they hold up against one of the most well-coached offenses in the NFL.
San Francisco head coach Kyle Shanahan has a way of scheming players open, so Minnesota's corners need to be on their A game.