1. Minnesota's offensive line
Through six weeks, the Vikings have one of the best offensive lines in the entire league, somehow, and as long as they continue to gel, they should give Kirk Cousins and the offensive weapons an opportunity to put up points on Monday.
Christian Darrisaw and Brian O'Neill are arguably the best tackle duo in the NFL, and no matter what side 49ers pass rusher Nick Bosa chooses in this week's matchup, he is going to have his work cut out for him.
The interior of Minnesota's offensive line has been much improved throughout this entire season, and with the likes of San Francisco's Javon Hargrave and Arik Armstead coming face-to-face with them, it will be this battle that ultimately defines the outcome of this game.
Vikings left guard Ezra Cleveland was unable to finish last week's game against the Chicago Bears, but backup Dalton Risner made the transition seamless when he entered the matchup. Now, Risner could potentially end up starting in place of an injured Cleveland on Monday.
There will be high expectations for him and the rest of Minnesota's offensive line in this week's game. But as long as Cousins is given time, he should be able to cut the 49ers' defense apart, even without Justin Jefferson to throw to.