49ers vs. Vikings prediction, odds, spread, injuries, trends for NFL Week 7

A full betting preview and prediction for the NFL Week 7 edition of Monday Night Football between the 49ers and Vikings.

Oct 15, 2023; Chicago, Illinois, USA;  Minnesota Vikings quarterback Kirk Cousins (8) hands off to
Oct 15, 2023; Chicago, Illinois, USA; Minnesota Vikings quarterback Kirk Cousins (8) hands off to / Jamie Sabau-USA TODAY Sports

The NFL Week 7 edition of Monday Night Football is an NFC showdown between the San Francisco 49ers and Minnesota Vikings.

Both teams are dealing with a plethora of injury with the Vikings still missing Justin Jefferson and the 49ers have several players on the injury list, including Christian McCaffrey, Trent Williams, and Deebo Samuel.

In this article, I'm going to give you everything you need to know to bet on the game.

For more Week 7 picks, check out our BetSided NFL betting analyst Iain MacMillan’s best bet for every game on the slate here!

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49ers vs. Vikings odds, spread, and total

49ers vs. Vikings betting trends

  • 49ers are 13-4 ATS in their last 17 games
  • 49ers are 4-2 ATS in their last six games vs. Vikings
  • 49ers are 1-4 ATS in their last five road games
  • 49ers have lost six-straight games vs. Vikings
  • Vikings are 3-8-1 ATS in their last 12 games
  • The UNDER is 5-1 in the Vikings' last six games
  • Vikings are 0-6 ATS in their last six home games

49ers vs. Vikings injury reports

San Francisco 49ers injury report

  • George Odum - S - Questionable
  • Deebo Samuel - WR - Questionable
  • Trent Williams - OT - Questionable
  • Dre Greenlaw - LB - Questionable
  • Christian McCaffrey - RB - Questionable

Minnesota Vikings injury report

  • Justin Jefferson - WR - IR
  • Ezra Cleveland - G - Questionable
  • Akayleb Evans - CB - Questionable
  • Jalen Nailor - WR - IR-R
  • Marcus Davenport - LB - IR

49ers vs. Vikings how to watch

  • Date: Monday, Oct. 23
  • Game Time: 8:15 p.m. EST
  • Venue: U.S. Bank Stadium
  • How to Watch (TV): ABC/ESPN
  • San Francisco 49ers Record: 5-1
  • Minnesota Vikings Record: 2-4

49ers vs. Vikings key players to watch

San Francisco 49ers

Brandon Aiyuk: If Christian McCaffrey and Deebo Samuel are both out for this game, all the pressure will be on the shoulders of Brandon Aiyuk. He's been having a career year, racking up 454 yards and two touchdowns through his first five games, but now he's going to be expected to take yet another step forward if the offense needs to rely on him to move the ball down the field against the Vikings.

Minnesota Vikings

Kirk Cousins: Much has been made about Kirk Cousins' record in prime time, and he already has a lost earlier this season against the Philadelphia Eagles. He has a chance to quiet the haters by beating arguably the best team in the NFL on Monday Night Football. Let's see if he can live up to the challenge.

49ers vs. Vikings prediction and pick

I've been betting on the Vikings virtually every week this season and I don't plan on stopping now. They continue to outperform their current record and are even sitting seventh in the NFL in Net Yards per Play heading into week 7.

Meanwhile, it seems like the 49ers are in a great spot to sell high. After looking like the best team in the NFL before Week 6, they have their three best players on the injury report and are due for a bit of a dip in their production.

Do the Vikings win outright? Hard to say, but they're a fantastic bet against the spread getting this many points at home.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!